Chloroquine-resistant plasmodium falciparum malaria is a serious public health threat that is spreading rapidly across Sub-Saharan Africa. It affects over three quarters (80%) of malarial endemic countries. Of the estimated 300-500 million cases of malaria reported annually, the vast majority of malarial-related morbidities occur among young children in Africa, especially those concentrated in the remote rural areas with inadequate access to appropriate health care services. In Liberia, in vivo studies conducted between 1993 and 2000 observed varying degrees of plasmodium falciparum (...) malaria infections that were resistant to chloroquine, including sulfadiazine-pyrimethamine. As the country emerges from a prolonged civil war, the health care delivery system may not be adequately prepared to implement an effective nation-wide malarial control strategy. As a result, the management of uncomplicated malaria in Liberia poses a significant public health challenge for the government-financed health care delivery system. Therefore, based on extensive literature review, we report the failure of chloroquine as an effective first-line drug for the treatment of uncomplicated plasmodium falciparum malaria in Liberia and recommend that national health efforts be directed at identifying alternative drug(s) to replace it. (shrink)

Each of us is uniquely subject to certain kinds of stimulation from a small part of the universe within our skins. Mentalistic psychologies insist that other kinds of events, lacking the physical dimensions of stimuli, are accessible to the owner of the skin within which they occur. One solution often regarded as behavioristic, granting the distinction between public and private events and ruling the latter out of consideration, has not been successful. A science of behavior must face the problem of (...) privacy by dealing with events within the skin in their relation to behavior, without assuming they have a special nature or must be known in a special way. (shrink)

The year 1927 is a landmark in the evolution of physics—the year which saw the obsequies of the notion of causality. To avoid misconceptions, it should not be thought that the concept fell a victim to the unbridled antipathy of certain physicists or their indulgence in fancies. The truth is that men of science came, very reluctantly and almost against their will, to recognize the impossibility of giving a coherent causal description of the happenings on the atomic scale, though some (...) of them—curiously enough, amongst them Planck, Einstein, de Broglie, Schrödinger—could never bring themselves to accept wholeheartedly so drastic a renunciation of classical ideals. (shrink)

Mcguiness finds in the early wittgenstein a metaphysics similar to\nthat of nature mysticism. he discusses the relation between this\nkind of mysticism and wittgenstein's views on logic, ethics, aesthetics,\noptimism, solipsism, and 'living in the present.' he suggests that\nwittgenstein may have had some kind of mystical experience which\ninfluenced his early philosophy. (staff).

definitions and explanations frequently come together and permeate almost all fields of knowledge. This does not exclude mathematics, even when these definitions hold clear links and close connections with our physical world. Here we propose a rather different perspective. Making operational physical assumptions, we show how it is possible to rigorously reconstruct some features of both geometry and topology. Broadly speaking, assuming this operational and more concrete philosophy we not only are capable of defining primitive concepts like points, straight lines, (...) planes, angles and spaces, but we also go all the way up to more complex constructions. We show that within our method it is also possible to come up with what we call a compass-based topology as well as a normed and a metric space. We hope this operationalist point-of-view can assist other researchers and students to have a clearer understanding of these quite abstract concepts. (shrink)

We owe most scientific knowledge to methods of inquiry that are never formally analyzed. The analysis of behavior does not call for hypothetico-deductive methods. Statistics, taught in lieu of scientific method, is incompatible with major features of much laboratory research. Squeezing significance out of ambiguous data discourages the more promising step of scrapping the experiment and starting again. As a consequence, psychologists have taken flight from the laboratory. They have fled to Real People and the human interest of “real life,” (...) to Mathematical Models and the elegance of symbolic treatments, to the Inner Man and the explanatory preoccupation with inferred internal mechanisms, and to Laymanship and its appeal to “common sense.” An experimental analysis provides an alternative to these divertissements.The “theories” to which objection is raised here are not the basic assumptions essential to any scientific activity or statements that are not yet facts, but rather explanations which appeal to events taking place somewhere else, at some other level of observation, described in different terms, and measured, if at all, in different dimensions. Three types of learning theories satisfy this definition: physiological theories attempting to reduce behavior to events in the nervous system; mentalistic theories appealing to inferred inner events; and theories of the Conceptual Nervous System offered as explanatory models of behavior. It would be foolhardy to deny the achievements of such theories in the history of science. The question of whether they are necessary, however, has other implications.Experimental material in three areas illustrates the function of theory more concretely. Alternatives to behavior ratios, excitatory potentials, and so on demonstrate the utility of rate or probability of response as the basic datum in learning. Functional relations between behavior and environmental variables provide an account of why learning occurs. Activities such as preferring, choosing, discriminating, and matching can be dealt with solely in terms of behavior, without referring to processes in another dimensional system. The experiments are not offered as demonstrating that theories are not necessary but to suggest an alternative. Theory is possible in another sense. Beyond the collection of uniform relationships lies the need for a formal representation of the data reduced to a minimal number of terms. A theoretical construction may yield greater generality than any assemblage of facts; such a construction will not refer to another dimensional system. (shrink)

It seems to make perfectly good sense to distinguish between what is expressed and the way in which it is expressed. There is little doubt that there are many different ways of saying the same thing open to us. If I denied this, I would certainly be wrong. And yet a word of caution may not be amiss. Among logicians a tendency has grown up to concentrate their attention on those properties of a statement which make it true or false, (...) what they call a “proposition”, and to neglect the form in which it is expressed. I think it is a dangerous tendency as it may lead to overlooking all sorts of differences which are due to the form. Let me give an example taken from F. P. Ramsey. (shrink)

I shall best approach my subject by explaining how it was that I, a non-professional, began to take an interest in Kafka. The fi rst thing of his which I happened to read was The Trial. It is diffi cult to describe my reaction. Certainly I didn’t understand the book. At fi rst sight it seemed to be a confused mass, a nightmare, something abstruse, incomprehensible to the utmost degree. One fi ne morning Joseph K., the junior manager of a (...) bank, is arrested. No grounds are given. He has, we are assured, done nothing wrong. A charge against him is never specifi ed. Though he is under arrest, he can walk about freely and go to his offi ce. In the course of the story we are led on to catch a glimpse of a very strange ‘Court’, a ridiculous, corrupt, despicable Court that sits in a suburb, in the attics of a building where the povertystricken tenants have fl ung their useless lumber. The Examining Magistrate sits on a kitchen chair, with an old horse-rug doubled under him. The Judges are obsessed with vanity, and run after every woman they see. (shrink)

The problem of causality is one of the central topics of Hume’s philosophy. There are several reasons for its importance: Of all the relations it is the only one in virtue of which we can pass beyond the immediate impression of the senses or an idea of the memory and thus step outside the realm of the given. The only relation “that can be trac’d beyond our senses, and informs us of existences and objects, which we do not see or (...) feel, is causation.” It is a relation which underlies our belief in an external world. To quote another passage from the Treatise: “We readily suppose an object may continue individually the same, tho’ several times absent and present to the senses; and ascribe to it an identity, notwithstanding the interruption of the perception, whenever we conclude, that if we had kept our eye or hand constantly upon it, it would have convey’d an invariable and uninterrupted perception. (shrink)

The major contributions of operationism have been negative, largely because operationists failed to distinguish logical theories of reference from empirical accounts of language. Behaviorism never finished an adequate formulation of verbal reports and therefore could not convincingly embrace subjective terms. But verbal responses to private stimuli can arise as social products through the contingencies of reinforcement arranged by verbal communities.

B F Scarlett; Formal and Teleological Elements in Hirst’s Argument for a Liberal Curriculum, Journal of Philosophy of Education, Volume 18, Issue 2, 30 May 2006.

Human behavior is the joint product of (i) contingencies of survival responsible for natural selection, and (ii) contingencies of reinforcement responsible for the repertoires of individuals, including (iii) the special contingencies maintained by an evolved social environment. Selection by consequences is a causal mode found only in living things, or in machines made by living things. It was first recognized in natural selection: Reproduction, a first consequence, led to the evolution of cells, organs, and organisms reproducing themselves under increasingly diverse (...) conditions. The behavior functioned well, however, only under conditions similar to those under which it was selected.Reproduction under a wider range of consequences became possible with the evolution of processes through which organisms acquired behavior appropriate to novel environments. One of these, operant conditioning, is a second kind of selection by consequences: New responses could be strengthened by events which followed them. When the selecting consequences are the same, operant conditioning and natural selection work together redundantly. But because a species which quickly acquires behavior appropriate to an environment has less need for an innate repertoire, operant conditioning could replace as well as supplement the natural selection of behavior.Social behavior is within easy range of natural selection, because other members are one of the most stable features of the environment of a species. The human species presumably became more social when its vocal musculature came under operant control. Verbal behavior greatly increased the importance of a third kind of selection by consequences, the evolution of social environments or cultures. The effect on the group, and not the reinforcing consequences for individual members, is responsible for the evolution of culture. (shrink)